Cheetah was a research scientist, exploring the possibilities of enhancing human capabilities with animal characteristics. Excited by the potential of her research, but without sufficient funding to continue, she was forced to use herself as a test subject, and transformed herself into a human-cheetah hybrid. She hoped to prove the value of her work, but instead made herself an outcast, and turned to crime as a source of continued funding.Batman described her as a person so devoted to her work that she was willing to give up her humanity for it; despite this, she is still insecure over her transformation and resents her outcast status. Lex Luthor recruited Cheetah as a member of his Injustice Gang to destroy the Justice League. In their first attempt, Cheetah masqueraded as a hostage being held by Ultra-Humanite and then attacked when Batman was lured too close to her. The Gang scored a success when Batman followed them to their hideout and was knocked out by Joker. Luthor assigned the Gang members to guard Batman in shifts. When Cheetah's turn came, she unexpectedly found herself sharing the story of her life with Batman, who was a sympathetic listener. Succumbing to a rush of attraction, she leaned in and planted a deep kiss on him. Later, when someone from the Gang called the League to warn them about a bomb Luthor had planted in the Watchtower, Luthor reviewed the hideout's surveillance cameras, saw the kiss, and ordered her taken away (though the traitor was later revealed to be the Humanite). Grundy dragged her away, presumably to be killed, but she was later seen in police custody with the rest of the gang, meaning she somehow escaped. A few years later, Cheetah was seen along with Copperhead, Blockbuster and KGBeast robbing a gold vault when the Justice League apprehended them. She battled Wonder Woman and was knocked out. Before the League could deliver them to the police, they were banished to another dimension by Mordred. Morgaine Le Faye showed up and after Mordred was stopped, it was assumed that the villains were likewise returned to the normal world.She later joined Grodd's Legion of Doom. Cheetah participated in the attack on Gorilla City but was defeated by Wonder Woman. There, she sided with Luthor against Grodd during the mutiny and she also helped the Justice League in the final battle against Darkseid. She was last seen fleeing the Metro Tower along with the other surviving members of the Legion.